Lost at 40 (ish) happened for me, a few weeks before my 41st birthday. As a side note this can happen at 20 (ish) 30 (ish) etc. I had been on the path of personal growth and awareness for many years. At the time, I was working for Starbucks as a manager, I walked into the store like I had done so many times before, but this time was different. I experienced an intense feeling of anxiety in my heart and a deep knowing that I was done.... I could no longer continue on the path of working there; in an environment that I now know and understand, was completely overwhelming for my nervous system. I imagine that for others the only choice would have been to keep going, regardless of what my body was screaming. Luckily for me, in previous years I had been able to experience the contrast of following my heart vs. following a career.